3-Amino-4-pyrazole carbosamide hemisulfate

N'etiti maka njikọ nke allopurinol.

Ọ bụ otu n'ime usoro pyrazole nke 3-amino-4 nọchiri anya ya.Enwere ike iji ya mee ihe dị ka etiti iji mepụta ọtụtụ ogige ọgwụ ọgwụ na-arụ ọrụ nke ọma, dị ka allopurinol, otu n'ime usoro ihe nrụpụta pyrazolopyrimidine, nke ikpeazụ kemgbe 1963 Ebe ọ bụ na ejiri ya na ụlọ ọgwụ, ọ bụ isi ọgwụ maka ọgwụgwọ gout.Ka ọ dị ugbu a, e nwere ụzọ ole na ole a ma ama maka nhazi

3-aminopyrazole-4-carboxamide hemisulfate na China, tumadi site na mmeghachi omume malononitrile na triethyl orthoformate iji kwadebe ethoxymethylene malononitrile, na mmeghachi omume nke hydrazine hydrate na-enweta 3-amino-4-cyanopyrazole, nke a na-emecha meghachi omume na-emepụta sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis nke 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), ngụkọta mkpụrụ nke njikọ site na usoro a bụ ihe dịka 60% (gbakọọ dị ka malononitrile), usoro a Ọ na-agụnye mmeghachi omume nke atọ, usoro ndị ahụ dị ogologo, na reagents eji, dị ka malononitrile na ethoxymethylene malononitrile, na-egbu egbu ma dị oke ọnụ.Tụkwasị na nke ahụ, 3-aminopyrazole-4 nke a kwadebere site na usoro a -Formamide hemisulfate nwere agba nke siri ike iwepụ ma na-achọ nhazi ọzọ, nke dị mgbagwoju anya.

Enwere akụkọ na akwụkwọ ndị mba ọzọ na-eji pyridylamide hydrazone na ethoxymethylene malononitrile dị ka akụrụngwa iji nweta 3-amino-4-cyanopyrazole site na mgbakwunye na cyclization, wee meghachi omume na sulfuric acid gbanyere mkpọrọgwụ iji nweta onyinye ebumnuche (Reuken G Jones. Mmeghachi omume nke orthoesters na ogige methylene na-arụ ọrụ[J]. J Am Chem Soc. 1952,74 (5) :4889 4891).Isi ihe eji eme ihe na usoro a dị oke ọnụ, mmepụta mmeghachi omume adịghị elu, na uru nke mmepụta mmepụta ihe dị ala.Ọ ga-abụrịrị ihe siri ike.