2-butyl-5-nitro-3-benzofuranyl)[4-[3- (dibutylaMino) propoxy] phenyl]

A na-eji ya n'ụlọ ọgwụ na hyperuricemia nke mbụ na nke abụọ, karịsịa na ndị ọrịa nwere hyperuricemia, yana ndị ọrịa na-arịa ọrịa akụrụ, yana ndị ọrịa nwere gout ugboro ugboro ma ọ bụ na-adịghị ala ala, yana ndị ọrịa nwere hyperuricemia.A na-eji ya na ndị ọrịa nwere Gouty nephropathy iji belata mgbaàmà ma belata nguzobe nke uric acid uric acid.nkume gout;eji na uric acid akụrụ nkume na uric acid akụrụ ọrịa.

Ọhụrụ mgbochi arrhythmic ọgwụ Atrial fibrillation (AF) bụ ọrịa nwere ike iyi ndụ egwu.N'ihi ịka nká nke ndị mmadụ, ọnụ ọgụgụ zuru ụwa ọnụ na ọnwụ nke fibrillation na-arịwanye elu, ọ ghọwokwa nsogbu ahụike ọha na eze ọhụrụ.Enwere ndị ọrịa nde 2.5 nwere fibrillation atrial na United States yana nde 4.5 na European Union.Dị ka ọnụ ọgụgụ si kwuo, ọnụ ọgụgụ nke fibrillation atrial n'etiti ndị mmadụ karịrị afọ 30 na mba m bụ 0.77%, nke na-abawanye na afọ, na ụmụ nwoke dị elu karịa ụmụ nwanyị (0.9%: 0.7%).Ọrịa ndị na-ebute fibrillation atrial na-agụnyekarị ọbara mgbali elu, ọrịa obi obi, ọrịa obi valvular, cardiomyopathy na-apụtaghị onwe ya, na nkụda mmụọ.Ihe mgbaàmà bụ isi nke ndị ọrịa nwere fibrillation atrial bụ ọnụ ọgụgụ ventricular na-adịghị agafe agafe, na njikwa ọnụọgụ obi na-anọkwa n'ọnọdụ ụfọdụ na nnukwu ọgwụgwọ na mmezi nke mgbaàmà.Amiodarone na-arụ ọrụ dị mma n'ịchịkwa ọnụ ọgụgụ obi na iweghachi ọgba aghara nke sinus, mana mmetụta ọjọọ nke akụkụ ahụ e lekwasịrị anya metụtara akụkụ iodine n'ime nhazi ya na-egbochi ngwa ụlọ ọgwụ ya, dị ka mmebi nke ngụgụ, thyroid, na imeju.Mmeghachi omume ọjọọ ndị a kpọtụrụ aha n'elu na nhazi ya nke iodine dị na ya nwere njikọ chiri anya.A nwetara ọgwụ ọhụrụ antiarrhythmic Dronedarone (Dronedarone) site n'ịgbanwe nhazi nke amiodarone.Dronedarone nwere akụrụngwa electrophysiological yiri amiodarone, mana enweghị ayodiin n'ụdị ya, yabụ ọ nwere ike zere mmetụta dị njọ na-emetụta obi ọzọ nke ayodiin Chemicalbook kpatara.A kwadoro Dronedarone maka ire ahịa site na US Food and Drug Administration (FDA) na July 2009, ma kwadoro maka ịzụ ahịa na European Union na 2009. Ọ bụkwa ọgwụ ọhụrụ antiarrhythmic ọhụrụ kwadoro na European Union n'ime afọ 10.Dronedarone bụ N-[2-butyl-3-[4-[3- (dibutylamino) propoxy] phenyl]-5-benzofuranyl]-methanesulfonamide, nke bụ iji belata ihe nrụpụta benzofuran nwetara site na ngbanwe nhazi nke amiodarone, nke na-abụghị nke a. mmeghachi omume ọjọọ nke obi.Ọ na-ewepụ atom ayodiin na amiodarone iji belata nsị nke thyroid na akụkụ ndị ọzọ;na-agbakwụnye otu methylsulfonyl n'akụkụ benzofuran iji belata lipophilicity, si otú ahụ na-ebelata ọkara ndụ nke ọgwụ na ibelata mkpokọta anụ ahụ mmetụta na ohere nke ọgwụ nke neurotoxicity.Ma ụdị 2011 US na 2010 European version nke Atrial Fibrillation Guidelines kwadoro dronedarone maka ọgwụgwọ nke fibrillation atrial.Dronedarone dị mma ma dị irè n'ịgwọ ọnụ ọgụgụ ventricular na ịnọgide na-enwe ọnụ ọgụgụ sinus na ndị ọrịa dị iche iche na-enweghị AF siri ike.Ọ nwere ike ịbụ ọgwụ dị irè iji dochie amiodarone.Dronedarone nwekwara ike ibelata ọnwụ nke ndị ọrịa AF na ọbụna ndị ọrịa AF na-adịgide adịgide.Ya mere, a na-atụ anya ka ọ bụrụ ọgwụ mbụ maka ndị ọrịa AF na-enweghị nkụda mmụọ siri ike.Ọzọkwa, iji ọgwụ mgbochi ọrịa na ndị ọrịa AF dị n'etiti ndị nwere nnukwu ihe ize ndụ bara uru maka iji dronedarone.