Ọ bụghị naanị na anyị ga-anwa ike anyị ịnye ụlọ ọrụ dị egwu maka onye ọ bụla na-azụ ahịa, mana dịkwa njikere ịnata aro ọ bụla nke ndị na-azụ ahịa anyị nyere maka ezigbo mma 99% 2-Cyanobenzyl Bromide;Alfa-Bromo-O-Toluonitrile CAS: 22115-41-9, Ndị otu ụlọ ọrụ anyị yana iji teknụzụ dị mkpụmkpụ na-ebuga ngwa ahịa na-enweghị atụ na-asọpụrụ ma nwee ekele maka atụmanya anyị gburugburu ụwa.
Ọ bụghị naanị na anyị ga-anwa ike anyị ịnye ụlọ ọrụ mara mma maka ihe fọrọ nke nta ka ọ bụrụ onye ọ bụla na-azụ ahịa, kamakwa anyị dị njikere ịnata aro ọ bụla nke ndị na-azụ ahịa anyị nyere.China 2-Cyanobenzyl Bromide ntụ ntụ na Alpha-Bromo-O-Toluonitrile, Anyị kwenyesiri ike na nkà na ụzụ na ọrụ bụ isi anyị taa na àgwà ga-emepụta mgbidi anyị pụrụ ịdabere na ya n'ọdịnihu.Naanị anyị nwere mma na mma mma, anyị nwere ike nweta ndị ahịa anyị na onwe anyị.Nabata ndị ahịa n'okwu niile ka ị kpọtụrụ anyị maka inwekwu azụmahịa na mmekọrịta ntụkwasị obi.Anyị na-anọ ebe a na-arụ ọrụ maka ihe ị chọrọ mgbe ọ bụla ị ga-achọ.
Jiri:Ọkara maka Linagliptin.
Jiri:Ọkara maka Linagliptin
Ọkọlọtọ ndị isi:ọkọlọtọ ụlọ ọrụ
Nyocha:98-102%
Mputa:Na-acha ọcha na ntụ ntụ edo edo
ngwugwu:25kg / agba
Iji nyochaa linagliptin dị adị na isi ya etiti 8-bromo-7- (2-butynyl) -3,7-dihydro-3-methyl-1-[(4-methyl -2-quinazolinyl) methyl) -1H-purine- 2,6-dione (11) usoro njikọ, chọta ụzọ sịntetik dabara adaba maka mmepụta mmepụta ihe.Usoro: chịkọta ụzọ dị iche iche sịntetik.Nsonaazụ na nkwubi okwu: Ụzọ 2.2 nwere usoro dị mfe na ọnụ ala dị ala, nke dabara adaba maka mmepụta mmepụta ihe.
8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione bụ isi etiti na njikọ nke ọgwụ hypoglycemic linagliptin.Njikọ nke 1 na-eji methyl urea na cyanoacetic acid dị ka ihe mmalite, ma na-enweta mmeghachi omume isii nke condensation, cyclization, nitrosation, mbelata, cyclization, na bromine na ngụkọta nke 46.3%.1HNMR kwadoro nhazi nke ndị etiti niile.
Ihe mepụtara ugbu a metụtara usoro nkwadebe dị mfe nke linagliptin dị ọcha.Quinazoline, isi ihe dị n'etiti maka nkwadebe otu ite nke linagliptin 8 bromo 7 (2 butyne 1 base) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, nke etiti bụ nke kewara. filtration, wee meghachi omume na (R) 3 aminopiperidine dihydrochloride iji nweta ngwọta nwere linagliptin.Mgbe emechara ihe ngwọta nwere linagliptin ọzọ, ngwaahịa Deliraliptin dị ọcha.Nkwadebe nke isi etiti nke ihe a na-emepụta ugbu a na-agbaso usoro otu ite, nke dị mma iji rụọ ọrụ ma na-eme ka mkpụrụ dị mma.Mgbe ekewasịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsị akwụkwọ), a na-emeghachi ya na (R)3 aminopiperidine dihydrochloride (R) 3 aminopiperidine dihydrochloride, si otú ahụ nweta linagliptin dị ọcha na-ezutekwa mmepụta na nkwupụta nke ụlọ ọrụ ọgwụ ruo oke.
Ọ bụghị naanị na anyị ga-anwa ike anyị ịnye ụlọ ọrụ dị egwu maka onye ọ bụla na-azụ ahịa, mana dịkwa njikere ịnata aro ọ bụla nke ndị na-azụ ahịa anyị nyere maka ezigbo mma 99% 2-Cyanobenzyl Bromide;Alfa-Bromo-O-Toluonitrile CAS: 22115-41-9, Ndị otu ụlọ ọrụ anyị yana iji teknụzụ dị mkpụmkpụ na-ebuga ngwa ahịa na-enweghị atụ na-asọpụrụ ma nwee ekele maka atụmanya anyị gburugburu ụwa.
Ogo dị mmaChina 2-Cyanobenzyl Bromide ntụ ntụ na Alpha-Bromo-O-Toluonitrile, Anyị kwenyesiri ike na nkà na ụzụ na ọrụ bụ isi anyị taa na àgwà ga-emepụta mgbidi anyị pụrụ ịdabere na ya n'ọdịnihu.Naanị anyị nwere mma na mma mma, anyị nwere ike nweta ndị ahịa anyị na onwe anyị.Nabata ndị ahịa n'okwu niile ka ị kpọtụrụ anyị maka inwekwu azụmahịa na mmekọrịta ntụkwasị obi.Anyị na-anọ ebe a na-arụ ọrụ maka ihe ị chọrọ mgbe ọ bụla ị ga-achọ.