N'izu a, akwụkwọ akụkọ agụmakwụkwọ kachasị elu Nature bipụtara akwụkwọ nyocha n'ịntanetị site n'aka ndị otu Prọfesọ Feng Liang na Mahadum Stanford, na-ekpughe nhazi na usoro arụ ọrụ nke protein mgbochi ụbụrụ ụbụrụ MFSD2A.Nchọpụta a na-enyere aka imepụta ọgwụ iji chịkwaa ihe mgbochi nke ụbụrụ ụbụrụ ọbara.
MFSD2A bụ onye na-ebufe phospholipid nke na-ahụ maka nnabata nke docosahexaenoic acid n'ime ụbụrụ n'ime sel endothelial nke mejupụtara ihe mgbochi ụbụrụ ọbara.Docosahexaenoic acid ka amara nke ọma dị ka DHA, nke dị mkpa maka mmepe na arụmọrụ nke ụbụrụ.Mgbanwe nke na-emetụta ọrụ nke MFSD2A nwere ike ịkpata nsogbu mmepe nke a na-akpọ ọrịa microcephaly.
Ike ibuga lipid nke MFSD2A pụtakwara na protein a nwere njikọ chiri anya na iguzosi ike n'ezi ihe nke mgbochi ụbụrụ ọbara.Nnyocha ndị gara aga achọpụtala na mgbe ọrụ ya belatara, ihe mgbochi ụbụrụ-ọbara ga-agbapụta.Ya mere, a na-ewere MFSD2A dị ka mgbanwe nchịkwa na-ekwe nkwa mgbe ọ dị mkpa ịgafe ihe mgbochi ụbụrụ ọbara iji nyefee ọgwụ ọgwụgwọ n'ime ụbụrụ.
N'ime ọmụmụ ihe a, Prọfesọ Feng Liang's otu jiri cryo-electron microscopy technology nweta elu-mkpebi Ọdịdị nke òké MFSD2A, na-ekpughe ya pụrụ iche extracellular ngalaba na mkpụrụ ejikọta oghere.
N'ịkọkọta nyocha ọrụ na ihe nleba anya nke mkpụrụ ndụ ihe nketa, ndị nchọpụta ahụ chọpụtakwara ebe nchekwa sodium echekwara na nhazi nke MFSD2A, na-ekpughe ụzọ ntinye lipid nwere ike ime, na inyere aka ịghọta ihe kpatara mgbanwe MFSD2A kpọmkwem na-akpata ọrịa microcephaly.
Oge nzipu: Sep-01-2021