Rivaroxaban (S)-Rivaroxaban;BAY 59-7939;RivaroxabanIsomer;Rivaroxaban;
Rivaroxaban (S)-Rivaroxaban;BAY 59-7939;RivaroxabanIsomer;Rivaroxaban;
A na-eji ya na ndị ọrịa toro eto nwere ịwa ahụ ngbanwe hip ma ọ bụ ikpere iji gbochie thrombosis venous (VTE).
A na-eji ya egbochi ma ọ bụ ibelata nhazi nke thrombosis, thrombosis miri emi (DVT) na pulmonary embolism (PE) mgbe ịwa ahụ dochie hip ma ọ bụ ikpere.
Usoro akwadoro bụ rivaroxaban ọnụ 10mg, otu ugboro n'ụbọchị.Enwere ike iji Rivaroxaban 10mg were nri ma ọ bụ naanị ya.Ekwesịrị iji nri were were Rivaroxaban 15mg ma ọ bụ 20mg mbadamba.
ọkọlọtọ: usp40
Nyocha: 99-102%
Mpụga: ọcha ntụ ntụ
ngwugwu: 25kg/drum
Were 4- (4-aminophenyl) morpholin-3-otu (SM-1), (S) -N-glycidyl phthalimide (SM-2), 5-chlorothiophene-2- Formyl chloride (SM-3) bụ ihe mmalite. .Mgbe condensation gasịrị, cyclization, aminolysis na acylation, a na-enweta rivaroxaban crude, na rivaroxaban emechara ka a nụchaa.
Nkwadebe: Ngwaahịa a bụ mbadamba ihe mkpuchi na-acha uhie uhie.
Ngwa:
Mbadamba ụrọ: microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, hypromellose, sodium lauryl sulfate, magnesium stearate.
Ihe mkpuchi: polyethylene glycol, hypromellose, titanium dioxide, iron oxide red
Rivaroxaban bụ ezigbo nhọrọ, ọgwụ ọnụ na-egbochi ihe Xa.Site na oke nhọrọ na ịsọ mpi nke mmechi nke free na bound Factor Xa na ọrụ prothrombin, gbatịkwuo oge thromboplastin na-arụ ọrụ (PT) na oge prothrombin (aPTT) n'ụzọ dabere na dose, nke nwere ike ịkwụsị mmiri mmiri coagulation The endogenous and exogenous paths na-egbochi mmepụta nke thrombin na thrombosis.Rivaroxaban anaghị egbochi thrombin (ihe na-arụ ọrụ Ⅱ), ma ọ bụ gosipụtaghị na ọ nwere mmetụta na platelet.
Ọdịiche dị mkpa dị n'etiti rivaroxaban na fondaparinux/heparin bụ na ọ chọghị itinye aka na antithrombin III ma nwee ike imegide ihe Xa;ebe heparin chọrọ antithrombin III ka ọ rụọ ọrụ, ọ nweghịkwa mmetụta na-akpata Xa na mgbagwoju prothrombin.
JIN DUN Medical nwereNtozu ISO ma mezuo ụkpụrụ mmepụta GMP, n'ọrụ ụlọ na mba ọzọ ọgwụ synthesis ọkachamara na ọgaranya ahụmahụ na-eduzi ụlọ ọrụ R&D.
TECHNOL OGY URU
● Nnukwu nrụgide catalytic Hydrogenation.Mmeghachi omume Hydrogenolysis nrụgide dị elu.Mmeghachi omume Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
●Mmeghachi omume
● Mkpebi Chiral
●Heck, Suzuki,Negishi,Sonogashira .Mmeghachi omume Gignard
Akụrụngwa
Ụlọ nyocha anyị nwere ngwaọrụ nnwale na nnwale dị iche iche, dị ka: NMR (Bruker 400M), HPLC, Chiral-HPLC, LC-MS, LC-MS/MS (API 4000) , IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Iche Iche Nyocha Calorimeter (DSC), Electron Microscope...
Otu R&D
Jindun Medical nwere otu ndị ọrụ R&D ọkachamara, ma were ọtụtụ ndị ọkachamara n'ime ụlọ na ndị mba ofesi na-eduzi R&D, na-eme ka njikọ anyị dịkwuo mma na nke ọma.
Anyị enyerela aka ọtụtụ ụlọ ọrụ na-emepụta ọgwụ ụlọ, dịkaHansoh, Hengrui na HEC Pharm.N'ebe a, anyị ga-egosi akụkụ nke ha.
Usoro nhazi nke mbụ:
Nọmba ekwentị: 110351-94-5
Nhazi nke abụọ:
Nọmba ekwentị: 144848-24-8
Usoro nke atọ:
Nọmba cas: 200636-54-0
1.Hazie ndị etiti ọhụrụ ma ọ bụ API.Otu dị ka nkesa nke dị n'elu, ndị ahịa nwere ihe achọrọ maka Intermediates ma ọ bụ API, na ha enweghị ike ịchọta ngwaahịa ndị dị mkpa na ahịa, mgbe ahụ anyị nwere ike inye aka hazie.
2.Usoro nkwalite maka ngwaahịa ochie.Ndị otu anyị ga-enyere aka ịkwalite ma melite mmepụta dị otú ahụ nke ụzọ mmeghachi omume ya mere ochie, ọnụ ahịa mmepụta dị elu, na arụmọrụ dị ala.Anyị nwere ike ịnye akwụkwọ zuru oke maka ịnyefe teknụzụ na nkwalite usoro, nyere ndị ahịa aka maka mmepụta nke ọma.
Site na ebumnuche ọgwụ ruo IND, JIN DUN Medical na-enye gịngwọta R&D ahaziri otu nkwụsị.
JIN DUN Medical na-ekwusi ike ịmepụta otu ndị nwere nrọ, na-emepụta ngwaahịa ndị nwere nsọpụrụ, ndị na-akpachapụ anya, siri ike, na-eme ka ọ bụrụ onye mmekọ tụkwasịrị obi na enyi ndị ahịa!
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