Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
![Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];Onyonyo ewepụtara](http://cdn.globalso.com/jindunchem-med/fbe17385.jpg)
Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
Ihe omume ndu nke Caspofungin Acetate
| Kọwaa | Caspofungin Acetate bụ ọgwụ antifungal nke nwere ike igbochi njikọ nke 1,3-β-d glucan synthase. |
| Ejikọtara yaedemede | ụzọ mgbaàmà Malite >> Mgbochi-efe efe >> Fungus Ebe nyocha >> oria |
| Na vivonyocha | Ụmụ oke ndị etinyere na caspofungin enweghị mgbanwe dị ịrịba ama na ebili mmiri ERG ha na mkpokọta vitreous nke 0.41 ruo 4.1 μM, na retina ha enweghị mgbanwe mgbanwe morphological ma ọ bụ mfu cell.Na mkpokọta vitreous nke 41 μM, caspofungin belatara njupụta nke ebili mmiri, ebili mmiri na nzaghachi scotopic nke ERG, ma mee ka mbelata ọnụ ọgụgụ sel dị na oyi akwa ganglion cell [1].Carprofungin (8 mg / kg) ma ọ bụ amphotericin B 1 mg / kg, injection intraperitoneal otu ugboro n'ụbọchị 30 awa mgbe ọrịa gasịrị maka ụbọchị 7, n'ihe metụtara ọgwụgwọ njikwa ụgbọ ala, ndụ 100% na ụbọchị 28, na-ebute ụbọchị 100% ọnụ ọgụgụ ọnwụ 11. , mgbe ihe ịma aka na-efe efe.E jiri ya tụnyere ọgwụgwọ njikwa ụgbọ ala na ụbọchị 5, caspofungin belatara mgbake nke Candida nwere ike ime na akụrụ na ụbụrụ ụbụrụ mgbe ibu njikwa ruru elu ya.Oke ejiri na caspofungin mee ihe na dose 2 mg / kg ma ọ bụ karịa nwere nnukwu ụbụrụ ụbụrụ dị ala n'ụbọchị 5 karịa ụmụ oke ejiri amphotericin B. Amphotericin B na ọgwụgwọ caspofungin belatara ibu ọrụ akụrụngwa akụrụngwa site na 1.7 log CFU/g na 2.46 ruo 3.64 log CFU. /g, n'otu n'otu [2]. |
| Anụmanụnnwale | A malitere ọgwụgwọ antifungal awa 30 ka ihe ịma aka na-efe efe gasịrị ma nye ya site na intraperitoneal (ip) injection otu ugboro n'ụbọchị maka ụbọchị 7.A na-eji 1, 2, 4, ma ọ bụ 8 mg / kg / ụbọchị caspofungin, 1 mg / kg / ụbọchị amphotericin B ma ọ bụ njikwa ụgbọ ala (mmiri distilled na-adịghị mma).A tụlere ịdị irè nke ihe nlereanya ahụ n'ụzọ atọ: site na nyochaa ọnụọgụ ndụ nke anụmanụ 10 n'ime otu ọgwụgwọ ọ bụla, site na nyochaa ibu Candida na akụrụ na ụbụrụ ụbụrụ nke ìgwè nke abụọ nke anụmanụ a na-emeso ya, na site n'ịtụle akụkọ ihe mere eme nke akụrụ.Na ụbụrụ.Nke atọ ìgwè mesoo ụmụ anụmanụ.The ụmụ oke euthanized site CO 2 inhalation na ịzụlite na 30 awa (ụgbọ ala na-emeso naanị) na ụbọchị 5 (24 awa mgbe 4th dose), 8 (24 awa mgbe ikpeazụ dose), na 14, 21 awa na histological. nlele anụ ahụ.(naanị ọgwụgwọ caspofungin), na 28 mgbe mwakpo ahụ gasịrị. |
| Ntụaka | [1].Mojumder DK, et al.Na-enyocha nsi retina nke intravitreal caspofungin na anya òké.Tinye ego nke Ophthalmol Vis Sci.2010 Nov; 51 (11): 5796-803 . [2].Flattery, Amy M. et al.Ịdị irè nke caspofungin n'ụdị òké ụmụaka nke sistem ụjọ etiti candidiasis.Ndị na-ahụ maka ọgwụ mgbochi na chemotherapy (2011), 55 (7), 3491-3497. |
Chemical na anụ ahụ nke caspofungin acetate
| Ebe esi nri | 1408.1ºC na 760 mmHg |
| Usoro ihe omimi | C56H96N10O19 |
| Ibu arọ molekụla | 1093.31000 |
| Ogo ziri ezi | 1092.64000 |
| PSA | 412.03000 |
| LogP | 0.06150 |
| Àgwà mpụta | na-acha ọcha ka agba aja aja |
| Uzuoku mgbali | 0mmHg na 25ºC |
| Ọnọdụ nchekwa | 20°C |
| Mmiri solubility | H2O: soluble15mg/mL (ihe ngwọta doro anya) |
Caspofungin Acetate Customs
| Koodu kọstọm | 2933990099 |
| Nchịkọta ndị China | 2933990099. Ogige heterocyclic ndị ọzọ nwere naanị nitrogen heteroatoms.Ọnụ ụtụ isi agbakwunyere ọnụ ahịa: 17.0%.Ọnụ ego nkwụghachi ụtụ: 13.0%.Ọnọdụ nchịkwa: Ọ dịghị.Tarifụ obodo kacha amasị ya: 6.5%.Tarifu izugbe: 20.0% |
| Ihe nkwupụta | Aha ngwaahịa, ihe eji eme ihe, ojiji, hexamethylene chloride, biko gosi ọdịdị ya, 6-caprolactam, biko gosi ọdịdị, ụbọchị nbinye aka. |
| Nchịkọta | 2933990090. ogige heterocyclic na nitrogen hetero-atom (s) naanị.VAT: 17.0%.Ọnụ ego nkwụghachi ụtụ: 13.0%..Tarifụ MFN: 6.5%.Tarifu izugbe: 20.0% |
Usoro mmepụta
Ekwesịrị ịkwadebe Caspofungin site na teknụzụ siri ike nke ọkara sịntetik.The crude ngwaahịa nke isi mgbanaka kwesịrị inweta site fermentation technology, na mgbe ahụ, a na-enweta etiti ngwaahịa site na nkewa na ịdị ọcha, mgbe ahụ, a na-eji ihe dị n'etiti dị ka ihe mmalite iji mezue splicing n'akụkụ site na iji teknụzụ sịntetik na-emecha nweta. ihe lekwasịrị anya.N'ihi na ngwaahịa "fermented semi-synthetic" kwesịrị ịgafe ọtụtụ njikọ teknụzụ dị ka gbaa ụka, nkewa na ịdị ọcha, njikọ, wdg, ụzọ teknụzụ na njikwa oke usoro dị mgbagwoju anya na Chemicalbook.Na mgbakwunye, ihe iwu chọrọ maka ndebanye aha caspofungin, ngwaahịa fermented ọkara sịntetik, dịkwa oke oke.Akwụkwọ anamachọihe kwesịrị ịmalite site na isi mmalite gbaa ụka, ọ bụghị naanị iji mụọ usoro ihe ọkụkụ, teknụzụ ịgba ụka, na teknụzụ sachaa, kamakwa iji nyochaa usoro njikọ.Ụzọ, ọnọdụ, na njikwa nke adịghị ọcha n'ime usoro ahụ, n'ihi na ngwaahịa ikpeazụ dị nnọọ nro, enweghị nlezianya ọ bụla ga-ehichapụ mgbalị niile gara aga, na ihe isi ike na nkà na ụzụ abụghị ihe dị mkpa.
Ọ bụ kpọmkwem n'ihi nnukwu ihe mgbochi teknụzụ dị elu yana ọmarịcha mpaghara asọmpi ka Hengrui Caspofungin jigidere oghere ọnụ ahịa dịtụ mma mgbe edepụtara ya.
Nchekwa patent kubiela n'afọ 2014
Ire nke injection caspofungin ọdụ na ụlọ ọrụ ahụike ọha na China (otu: puku yuan iri)
Ruo ugbu a, ọ bụ naanị ọgwụ nje Hengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals na Haisco ka akwadoro maka ịdepụta.Ọgwụ Huadong?
Ụlọ ọrụ nyocha mbụ nke caspofungin acetate bụ Merck, na ntinye aha nke ụlọ ọrụ 6 na-enyocha na nkwenye, ya bụ Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Sihuan Pharmaceutical, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, na Tianceuticals Biopharmaceutical.
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TECHNOL OGY URU
● Nnukwu nrụgide catalytic Hydrogenation.Mmeghachi omume Hydrogenolysis nrụgide dị elu.Mmeghachi omume Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
●Mmeghachi omume
● Mkpebi Chiral
●Heck, Suzuki,Negishi,Sonogashira .Mmeghachi omume Gignard
Akụrụngwa
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