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5,6,7,7a-tetrahydrothieno(3,2-c) pyridine-2(4h) -otu hydrochloride

5,6,7,7a-tetrahydrothieno(3,2-c) pyridine-2(4h) -otu hydrochloride

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CAS no: 115473-15-9

Njirimara kemịkalụ: Prasugrel Intermediates


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Na-eji

5,6,7,7a-tetrahydrothieno (3,2-c) pyridine-2 (4h) - otu hydrochloride na-eji dị ka etiti nke Prasugrel.

Prasugrel bụ thiophenopyridine antiplatelet mepụtara nke Eli Lilly na daiichisankyo, onye na-emepụta ọgwụ na Japan.Ọ bụ precursor ọgwụ.Ọ na-etolite molekul na-arụ ọrụ mgbe metabolism site na cytochrome P450 n'ime imeju ma jikọta ya na onye na-anabata platelet P2Y12 iji mee ihe na-arụsi ọrụ ike megide nchịkọta platelet.Nnyocha ụlọ ọgwụ egosila na dose 60 mg nwere mmetụta anticoagulant ka mma karịa 300 mg ọkọlọtọ dose na 600 mg na-abawanye dose nke clopidogrel, nke nwere ike belata ihe egwu nke nkụchi obi, ọrịa strok na ọnwụ n'ihi ọrịa obi site na 20%, ma nwee mmetụta ngwa ngwa. , mmetụta ọgwụgwọ dị mma, ezigbo mgbochi ọgwụ na bioavailability, na obere nsị.


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